The Coronavirus Is Mutating. What Does That Mean for Us?

Just as vaccines begin to offer hope for a path out of the pandemic, officials in Britain on Saturday sounded an urgent alarm about what they called a highly contagious new variant of the coronavirus circulating in England.

Citing the rapid spread of the virus through London and surrounding areas, Prime Minister Boris Johnson imposed the country’s most stringent lockdown since March. “When the virus changes its method of attack, we must change our method of defense,” he said.

In South Africa, a similar version of the virus has emerged, which seems to share some of the mutations seen in the British variant. That virus has been found in 90 percent of the samples whose genetic sequences have been analyzed in South Africa.

Scientists are worried about these variants but not surprised by them. Researchers have recorded thousands of tiny modifications in the genetic material of the coronavirus as it has hopscotched across the world.

Some variants become more common in a population simply by luck, not because the changes somehow supercharge the virus. But as it becomes more difficult for the pathogen to survive — because of vaccinations and growing immunity in human populations — researchers also expect the virus to gain useful mutations enabling it to spread more easily or to escape detection by the immune system.

“It’s a real warning that we need to pay closer attention,” Jesse Bloom, an evolutionary biologist at the Fred Hutchinson Cancer Research Center in Seattle. “Certainly these mutations are going to spread, and, definitely, the scientific community — we need to monitor these mutations and we need to characterize which ones have effects.”

The British variant has about 20 mutations, including several that affect how the virus locks onto human cells and infects them. These mutations may allow the variant to replicate and transmit more efficiently, said Muge Cevik, an infectious disease expert at the University of St. Andrews in Scotland and a scientific adviser to the British government.

But the estimate of greater transmissibility — British officials said the variant was as much as 70 percent more transmissible — is based on modeling and has not been confirmed in lab experiments, Dr. Cevik added.

“Over all, I think we need to have a little bit more experimental data,” she said. “We can’t entirely rule out the fact that some of this transmissibility data might be related to human behavior.”

In South Africa, too, scientists were quick to note that human behavior was driving the epidemic, not new mutations whose effect on transmissibility had yet to be quantified.

The British announcement also prompted concern that the virus might evolve to become resistant to the vaccines just now rolling out. The worries are focused on a pair of alterations in the viral genetic code that may make it less vulnerable to certain antibodies.

But several experts urged caution, saying it would take years — not months — for the virus to evolve enough to render the current vaccines impotent.

“No one should worry that there is going to be a single catastrophic mutation that suddenly renders all immunity and antibodies useless,” Dr. Bloom said.

“It is going to be a process that occurs over the time scale of multiple years and requires the accumulation of multiple viral mutations,” he added. “It’s not going to be like an on-off switch.”

Like all viruses, the coronavirus is a shape-shifter. Some genetic changes are inconsequential, but some may give it an edge.

Scientists fear the latter possibility, especially: The vaccination of millions of people may exert enormous pressure on the virus to become resistant to the immune response, setting back the global fight by years.

Already, there are small changes in the virus that have arisen independently multiple times across the world, suggesting the mutations are helpful to the pathogen. The mutation affecting antibody susceptibility — technically called the 69-70 deletion, meaning there are missing letters in the genetic code — has been seen at least three times: in Danish minks, in people in Britain and in an immune-suppressed patient who became much less sensitive to convalescent plasma.

“This thing’s transmitting, it’s acquiring, it’s adapting all the time,” said Dr. Ravindra Gupta, a virologist at the University of Cambridge, who last week detailed the deletion’s recurrent emergence and spread. “But people don’t want to hear what we say, which is: This virus will mutate.”

The new genetic deletion changes the spike protein on the surface of the coronavirus, which it needs to infect human cells. Variants of the virus with this deletion arose independently in Thailand and Germany in early 2020, and became prevalent in Denmark and England in August.

Scientists initially thought the new coronavirus was stable and unlikely to escape vaccine-induced immune response, said Dr. Deepti Gurdasani, a clinical epidemiologist at Queen…